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X-WR-CALDESC:Events for Global Biodefense
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DTSTART;TZID=Europe/Paris:20250319T130000
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UID:62221-1742389200-1742412600@globalbiodefense.com
SUMMARY:What Research is Important to Prepare for H5N1 Outbreaks?
DESCRIPTION:The World Health Organization will host a virtual meeting on 19 March to identify the knowledge gaps and priority research questions related to the development and evaluation of medical countermeasures to prepare for and respond to H5N1 outbreaks \nThe meeting will outline regulatory pathways for mRNA vaccines and other novel approaches and review other therapeutics\, including monoclonal antibodies and long-acting antivirals. \nH5N1 influenza virus infection can cause a range of diseases in humans\, from mild to severe and in some cases\, it can even be fatal. Symptoms reported have primarily been respiratory\, but conjunctivitis and other non-respiratory symptoms have also been reported. There have also been a few detections of A(H5N1) virus in persons who were exposed to infected animals or their environments but who did not show any symptoms. \nThe goose/Guangdong-lineage of H5N1 avian influenza viruses first emerged in 1996 and has been causing outbreaks in birds since then. Since 2020\, a variant of these viruses has led to an unprecedented number of deaths in wild birds and poultry in many countries. First affecting Africa\, Asia and Europe\, in 2021\, the virus spread to North America\, and in 2022\, to Central and South America. From 2021 to 2022\, Europe and North America observed their largest and most extended epidemic of avian influenza with unusual persistence of the virus in wild bird populations. \nSince 2022\, there have been increasing reports of deadly outbreaks among mammals also caused by influenza A(H5) – including influenza A(H5N1) – viruses. There are likely to be more outbreaks that have not been detected or reported. Both land and sea mammals have been affected\, including outbreaks in farmed fur animals\, seals\, sea lions\, and detections in other wild and domestic animals such as foxes\, bears\, otters\, raccoons\, cats\, dogs\, cows\, goats and others. \nWHO works with countries to help them prevent\, detect and manage cases of H5N1 virus infection in humans when they occur. WHO collaborates with global health partners and agencies\, including the World Organization for Animal Health (WOAH)\, and the Food and Agriculture Organization of the United Nations (FAO)\, to monitor the risk\, and control and prevent the spread of animal diseases. \nWHO’s global laboratory system\, the Global Influenza Surveillance and Response System (GISRS)\, identifies and monitors strains of circulating influenza viruses\, and provides advice to countries on their risk to human health and available treatment or control measures. WHO works with partners around the world on pandemic preparedness for H5N1 and other animal influenzas. \nInfluenza H5 pathogens have been included in the list of priority pathogens by the WHO R&D Blueprint for Epidemics. To coordinate efforts for research preparedness of H5N1 outbreaks\, this global consultation will review current and novel vaccines and preventive pharmaceuticals. \nPlease visit the World Health Organization’s website for more information and to register.
URL:https://globalbiodefense.com/event/what-research-is-important-to-prepare-for-h5n1-outbreaks/
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DTSTART;TZID=America/New_York:20250325T120000
DTEND;TZID=America/New_York:20250325T130000
DTSTAMP:20250322T191531Z
CREATED:20250322T191453Z
LAST-MODIFIED:20250322T191531Z
UID:62284-1742904000-1742907600@globalbiodefense.com
SUMMARY:Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery
DESCRIPTION:As part of Advancing Drug Discovery: A Webinar Series of the National Academies of Sciences\, Engineering and Medicine\, a session on Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery will be held on March 25th\, 2025. \nCryo-EM has emerged as a powerful structural technique that is generally applicable to samples spanning from single proteins to large viruses\, including integral membrane proteins and large macromolecular assemblies\, even when they are flexible or involve transient\, regulatory interactions. The minimal requirement concerning sample amount and the capacity to describe conformational ensembles make cryo-EM the technique of choice when characterizing samples that challenge methods like NMR or crystallography. \nThe resolution of the structures obtained by cryo-EM has been increasing with improvement in hardware and software\, making it relevant in the drug discovery arena. \nDr. Eva Nogales\, Distinguished Professor in Molecular and Cell Biology at the University of California\, Berkeley\, will introduce the technique and demonstrate its capability in studies of the microtubule cytoskeleton\, molecular machinery involved in gene expression regulation\, and other biological systems that had defied structural characterization by more traditional methods. \nPlease visit the National Academies’ Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery event page for more information and to register.
URL:https://globalbiodefense.com/event/unique-capabilities-of-cryo-em-in-structure-determination-and-its-potential-in-drug-discovery/
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DTSTART;TZID=America/New_York:20250326T090000
DTEND;TZID=America/New_York:20250326T130000
DTSTAMP:20250322T172829Z
CREATED:20250322T172829Z
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UID:62256-1742979600-1742994000@globalbiodefense.com
SUMMARY:50 Years of the Biological Weapons Convention: What Comes Next?
DESCRIPTION:Please join the National Academies of Sciences\, Engineering\, and Medicine on March 26\, 2025 for an event reflecting on the past 50 years of the Biological Weapons Convention. \nThe event will include: \n\nDiscussion of accomplishments\, lessons learned\, and looking ahead from the first 50 years that inform the next 50 years.\nEffects of science and technology on the future of the BWC and its relevance for eliminating biological weapons of the past and future.\nOpportunities for innovation in nonproliferation by expanding active participation of relevant sectors and disciplines\, more countries\, and new experts.\n\nSpeakers will explore the evolving role of science and technology in shaping the future of the Biological Weapons Convention and its relevance in eliminating biological weapons. Additionally\, the event will highlight opportunities for innovation in nonproliferation\, emphasizing the need to broaden participation across sectors\, disciplines\, and countries\, and engage new experts. \nHighlighted speakers include: \n\nAmbassador Bonnie Jenkins\nSonia Ben Ouagrham-Gormley\, George Mason University\nNancy Connell\, National Academies\nDave Stiefel\, Nuclear Threat Initiative\nGigi Gronvall\, Johns Hopkins Center for Health Security\nJohn Moulton\, Council on Strategic Risks\nDaniel Correa\, Federation of American Scientists\nJulie Fischer\, Georgetown University\, USA\nMaria Espona\, National Defense School\, Argentina\n\nPlease visit the National Academies’ 50 Years of the Biological Weapons Convention: What Comes Next? event page to register.
URL:https://globalbiodefense.com/event/50-years-of-the-biological-weapons-convention-what-comes-next/
LOCATION:https://www.youtube.com/watch?v=VR6w_YN1TSI
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DTSTART;TZID=America/New_York:20250327T140000
DTEND;TZID=America/New_York:20250327T160000
DTSTAMP:20250322T182141Z
CREATED:20250322T182141Z
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UID:62269-1743084000-1743091200@globalbiodefense.com
SUMMARY:Building Trust in the H5N1 Response: Perspectives from the Field
DESCRIPTION:The National Academies will host a event on Building Trust in the H5N1 Response: Perspectives from the Field via webcast on March 27\, 2025. \nAvian influenza is a growing threat to both human and animal health. In March 2024\, avian influenza (H5N1) was detected for the first time ever in dairy cattle. The ongoing H5N1 outbreak in the United States has impacted livestock\, diminished livestock production\, decimated wildlife\, and resulted in human infections. The potential for viral mutation and transmission poses a continued threat to human health. Despite the urgency of this evolving situation\, response has been hindered by a lack of trust among key stakeholders. Varying policies at national\, state\, and local levels have led to challenges in mitigation efforts. Following a National Academies workshop on potential research priorities to inform the H5N1 response\, the National Academies Forum on Microbial Threats will host a webinar in which agriculture producers and workforce health specialists will discuss their perspectives on steps that would build greater trust between producers and health officials to enable a more coordinated One Health response. \nThe Forum invites individuals who have been involved in response to the ongoing North American H5N1 outbreak to share their experiences and perspectives on building trust between agriculture producers and public health officials. Comments may be used to develop discussion questions and identify key topics of discussion for the webinar. Input is welcome from interested parties included\, but not limited to: \n\nState and local public health officials\nLivestock production specialists\nLivestock producers and workers\nOccupational health specialists\nEpidemiologists\nVeterinarians\n\n\n\nPlease visit the National Academies’ Building Trust in the H5N1 Response: Perspectives from the Field event page for more information and to register.
URL:https://globalbiodefense.com/event/building-trust-in-the-h5n1-response-perspectives-from-the-field/
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