Wednesday, February 1, 2023
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Biosecurity

iBio Adds Anthrax Antibodies to Product Pipeline

by Global Biodefense Staff
February 26, 2015
Military Research on Monoclonal Antibody Treatments

Credit: Shutterstock

iBio, Inc. today announced the issue of a US patent for “Compositions and Methods for Production of Immunoglobulins.”

Claims involve human monoclonal antibodies specifically recognizing the Protective Antigen (PA) or the Lethal Factor (LF) of Bacillus anthracis, the bacteria causing anthrax.

In mouse and non-human primate studies such antibodies, produced with the use of iBio’s iBioLaunch gene expression platform technology, prevented death in 100% of animals given an otherwise lethal doses of anthrax spores.

iBio has previously been issued similar patents in China, India, Korea and Europe.

“This technology continues the expansion of iBio’s antibody portfolio and broadens our patent protection for product candidates addressing anthrax, both for natural outbreaks and for possible biodefense considerations,” said Wayne P. Fitzmaurice Ph.D., iBio’s Vice President, Intellectual Property. “These monoclonal antibodies will complement our vaccine technology such as is described in our U.S. patent 8,277,816 covering compositions of matter and methods of producing and formulating anthrax vaccines.”

“A non-glycosylated version of this antibody binds PA, neutralizes anthrax LeTx activity in vitroand possesses superior efficacy compared with the glycosylated form of this antibody in non-human primates – a significantly longer half-life and 100% protection against a lethal dose of aerosolized anthrax spore challenge after a single i.v. administration,” said Terence Ryan, Ph.D., Chief Scientific Officer of iBio.  “These results suggest that this monoclonal antibody may be a useful tool for the treatment of inhalation anthrax in humans.”

In addition to its proprietary fibrosis therapeutic program and the production of monoclonal antibody candidates, iBio is exploring the commercialization of its iBioLaunch gene expression platform technology for viral and bacterial infectious disease applications through collaborations with third parties.

The company’s technology has been successfully applied to the development of an anthrax vaccine candidate, and a Phase 1 clinical trial of the safety and immunogenicity of this experimental vaccine, produced at the Fraunhofer USA Center for Molecular Biotechnology under a research license from iBio, is being conducted at Walter Reed Army Institute of Research.

Tags: AnthraxBioterrorismWRAIR

Related Posts

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions
Pathogens

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

January 25, 2023
DARPA Selects Teams to Develop Vaccine Durability Prediction Model
Medical Countermeasures

DARPA Selects Teams to Develop Vaccine Durability Prediction Model

January 13, 2023
small glass vials on an assembly line await filling of vaccine solution
Industry News

Sabin Vaccine Institute to Advance Ebola Sudan and Marburg Vaccines with New BARDA Funding

January 12, 2023
How Are Bivalent COVID Vaccines Stacking Up Against Omicron?
Infectious Diseases

How Are Bivalent COVID Vaccines Stacking Up Against Omicron?

January 12, 2023
Load More

Latest News

Partner Therapeutics’ Novel Approach to Stratify Sepsis Patients Gains Backing From BARDA

Biopreparedness Research Virtual Environment (BRaVE) Initiative Backed by $105M DOE Funding

January 25, 2023
Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

January 25, 2023
Biodefense Headlines – 24 January 2023

Biodefense Headlines – 24 January 2023

January 24, 2023
Biodefense Headlines – 17 January 2023

Biodefense Headlines – 17 January 2023

January 17, 2023

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC