Wednesday, May 18, 2022
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Funding News

National Toxicology Program Seeks Support to Examine Test Articles for Genetic Changes

by Global Biodefense Staff
January 22, 2019
Ames Genotoxicity

The Ames test for mutagenicity using Salmonella typhimurium histidine auxotrophs. Credit: Histidine via Wikipedia, modified

The National Institute of Environmental Health Sciences (NIEHS), in support of the National Toxicology Program (NTP), is conducting market research to formulate a procurement strategy for obtaining support to examine a variable number of test articles annually for induction of genetic changes.

For this requirement, the contractor must have the capability to:

  • Test approximately 20 chemicals per year for induction of gene mutations in bacterial tester strains (Ames test)
  • Measure chromosomal changes and DNA damage in tissue samples obtained from laboratory animals and shipped to the contractor from a remote NTP testing laboratory
  • Approximately 400 such samples may be evaluated annually
  • Test approximately 20 chemicals per year for induction of chromosomal changes and DNA damage in human and mammalian cell cultures
  • Measure molecular biomarkers of genetic change including but not limited to gene expression changes and DNA sequence changes.

The contractor should have experience conducting high throughput (96-well) in vitro mammalian cell assays for DNA damage and chromosome damage to enhance efficiency and statistical power. Data from in vivo and in vitro micronucleus assays will routinely be collected using flow cytometry methods.

Additional requirements are detailed in Solicitation Number: NIHES2019_RFI_GENETOX.

Tags: GenomicsRFIToxicology

Related Posts

NIH to Further Invest in Point-of-Care Technologies Research Network
Biodetection

NIH to Further Invest in Point-of-Care Technologies Research Network

May 10, 2022
U.S. Fish and Wildlife Service Opens Grant Program to Shore Up Avian Flu Biosecurity
Biosecurity

U.S. Fish and Wildlife Service Opens Grant Program to Shore Up Avian Flu Biosecurity

April 13, 2022
Send in the Blow Flies: Using Insects to Sample Areas for Chemical Warfare Agents
CBRNE

Send in the Blow Flies: Using Insects to Sample Areas for Chemical Warfare Agents

April 11, 2022
Johns Hopkins: Chemical in Leafy Greens May Slow Growth of Coronaviruses
Pathogens

Johns Hopkins: Chemical in Leafy Greens May Slow Growth of Coronaviruses

April 11, 2022
Load More

Latest News

NIH to Further Invest in Point-of-Care Technologies Research Network

NIH to Further Invest in Point-of-Care Technologies Research Network

May 10, 2022

How a COVID-19 Infection Spurs Antibodies Against Common Colds

May 8, 2022
Hospitals Resilience to Extreme Events: One-Third of Staff May Be Lost During a Disaster

Hospitals Resilience to Extreme Events: One-Third of Staff May Be Lost During a Disaster

May 6, 2022
Where is Testing Needed Most During Pandemic Surges? WVU Researchers Develop Machine Learning Prediction Tools

Where is Testing Needed Most During Pandemic Surges? WVU Researchers Develop Machine Learning Prediction Tools

May 6, 2022

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC