Friday, January 27, 2023
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Funding News

National Toxicology Program Seeks Support to Examine Test Articles for Genetic Changes

by Global Biodefense Staff
January 22, 2019
Ames Genotoxicity

The Ames test for mutagenicity using Salmonella typhimurium histidine auxotrophs. Credit: Histidine via Wikipedia, modified

The National Institute of Environmental Health Sciences (NIEHS), in support of the National Toxicology Program (NTP), is conducting market research to formulate a procurement strategy for obtaining support to examine a variable number of test articles annually for induction of genetic changes.

For this requirement, the contractor must have the capability to:

  • Test approximately 20 chemicals per year for induction of gene mutations in bacterial tester strains (Ames test)
  • Measure chromosomal changes and DNA damage in tissue samples obtained from laboratory animals and shipped to the contractor from a remote NTP testing laboratory
  • Approximately 400 such samples may be evaluated annually
  • Test approximately 20 chemicals per year for induction of chromosomal changes and DNA damage in human and mammalian cell cultures
  • Measure molecular biomarkers of genetic change including but not limited to gene expression changes and DNA sequence changes.

The contractor should have experience conducting high throughput (96-well) in vitro mammalian cell assays for DNA damage and chromosome damage to enhance efficiency and statistical power. Data from in vivo and in vitro micronucleus assays will routinely be collected using flow cytometry methods.

Additional requirements are detailed in Solicitation Number: NIHES2019_RFI_GENETOX.

Tags: GenomicsRFIToxicology

Related Posts

Partner Therapeutics’ Novel Approach to Stratify Sepsis Patients Gains Backing From BARDA
Funding News

Biopreparedness Research Virtual Environment (BRaVE) Initiative Backed by $105M DOE Funding

January 25, 2023
Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions
Pathogens

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

January 25, 2023
DARPA Selects Teams to Develop Vaccine Durability Prediction Model
Medical Countermeasures

DARPA Selects Teams to Develop Vaccine Durability Prediction Model

January 13, 2023
The device appears smaller than a playing card, transparent, with visible channels branching off.
Medical Countermeasures

How Organ-on-a-chip Models Could Grease the Drug Development Pipeline

January 10, 2023
Load More

Latest News

Partner Therapeutics’ Novel Approach to Stratify Sepsis Patients Gains Backing From BARDA

Biopreparedness Research Virtual Environment (BRaVE) Initiative Backed by $105M DOE Funding

January 25, 2023
Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

January 25, 2023
Biodefense Headlines – 24 January 2023

Biodefense Headlines – 24 January 2023

January 24, 2023
Biodefense Headlines – 17 January 2023

Biodefense Headlines – 17 January 2023

January 17, 2023

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC