Thursday, December 12, 2019
News on Pathogens and Preparedness
Global Biodefense
No Result
View All Result
  • Featured
  • Pathogens

    Tracing the Ancestral Genome of The Plague

    Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus

    Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus

    African Swine Fever: An Unexpected Threat to the Global Supply of Heparin

    African Swine Fever: An Unexpected Threat to the Global Supply of Heparin

    Bacillus anthracis concept drawing

    Decontamination of Bacillus Spores from Drinking Water Infrastructure

    MERS-CoV: Novel Zoonotic Disease Outbreak a Hard Lesson for Healthcare

    MERS-CoV: Novel Zoonotic Disease Outbreak a Hard Lesson for Healthcare

    red agar plate with cultured bacteria

    Study Shows Virulence of B. pseudomallei Strain in Aerosol Model

    Turns Out, Bat Influenza Can Give You the Flu

    Turns Out, Bat Influenza Can Give You the Flu

    Crimean-Congo Hemorrhagic Fever

    Crimean Congo Countermeasures: Researchers Investigate CCHFV-RDRp

    Yersinia pestis

    Researchers Optimize Novel Hexaplex PCR Assay for Simultaneous Detection of Anthrax and Plague Pathogens

  • Directory
  • Job Board
  • Funding
    • Contracts + Grants
    • Funding Awards
    • Requests for Information
    • Industry News
  • Events
    • All Events
    • Conferences + Meetings
    • Deadlines
    • Webinar-Webcast
    • Awareness Events
  • Headlines
  • Subscribe
  • Featured
  • Pathogens

    Tracing the Ancestral Genome of The Plague

    Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus

    Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus

    African Swine Fever: An Unexpected Threat to the Global Supply of Heparin

    African Swine Fever: An Unexpected Threat to the Global Supply of Heparin

    Bacillus anthracis concept drawing

    Decontamination of Bacillus Spores from Drinking Water Infrastructure

    MERS-CoV: Novel Zoonotic Disease Outbreak a Hard Lesson for Healthcare

    MERS-CoV: Novel Zoonotic Disease Outbreak a Hard Lesson for Healthcare

    red agar plate with cultured bacteria

    Study Shows Virulence of B. pseudomallei Strain in Aerosol Model

    Turns Out, Bat Influenza Can Give You the Flu

    Turns Out, Bat Influenza Can Give You the Flu

    Crimean-Congo Hemorrhagic Fever

    Crimean Congo Countermeasures: Researchers Investigate CCHFV-RDRp

    Yersinia pestis

    Researchers Optimize Novel Hexaplex PCR Assay for Simultaneous Detection of Anthrax and Plague Pathogens

  • Directory
  • Job Board
  • Funding
    • Contracts + Grants
    • Funding Awards
    • Requests for Information
    • Industry News
  • Events
    • All Events
    • Conferences + Meetings
    • Deadlines
    • Webinar-Webcast
    • Awareness Events
  • Headlines
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Antimicrobial Resistance

Carb-X Funds Techulon’s Rapidly Adaptable Nano Therapeutic in Fight Against Drug Resistant Bacteria

Techulon project is the 50th project funded by CARB-X since it was launched in 2016

by Global Biodefense
11 Nov 2019
Carb-X Funds Techulon’s Rapidly Adaptable Nano Therapeutic in Fight Against Drug Resistant Bacteria

CARB-X is awarding Techulon Inc., located in the Virginia Tech Corporate Research Center in Blacksburg, VA, USA, up to $785,000 in non-dilutive funding to develop a new class of antimicrobial that would kill drug-resistant bacteria by targeting specific genes critical to the bacteria’s survival.

The CARB-X award supports preclinical hit-to-lead development of Techulon’s drug candidates targeting Acinetobacter baumannii and Pseudomonas aeruginosa, two superbugs that have been identified by the World Health Organization (WHO) as ‘priority pathogens’ posing the greatest threat to global health and by the US Centers for Disease Control and Prevention (CDC) as ‘serious threats’ to human health.

The Techulon project is the 50th innovative antibacterial early development project funded by CARB-X, established in July 2016. To date, CARB-X has invested more than $150 million in non-dilutive funding to accelerate the development of antibiotics, vaccines, diagnostics and other life-saving products to address drug-resistant bacteria, with additional funds committed if projects achieve certain milestones. The CARB-X portfolio has 31 active projects in five countries.

Techulon is developing novel peptide-peptide nucleic acids (PPNAs) antimicrobial compounds using its RANT platform, which can reveal DNA sequences in genes that are essential for the survival of microbes. The drugs work by precisely targeting these genes in superbugs causing an infection, thereby killing them. The PPNAs are composed of cell-penetrating peptides (CPP) conjugated via linkers to a gene target-specific antisense peptide nucleic acid (PNA) sequence for improved delivery into the microbe cytoplasm, efficient binding to target mRNA, and inhibition of translation of the target gene.

“CARB-X is fighting the spread of drug-resistant bacteria by supporting the development of innovative therapeutics and other products that target the most serious bacterial threats. We are making progress,” said Kevin Outterson, Executive Director of CARB-X, which is based at the Boston University School of Law. “The Techulon project is in the early stages of development but if successful and approved for use in patients, it could represent major improvements in the way deadly infections are treated.” CARB-X is a consortium led by Boston University and funded by a global partnership.

Infections from drug-resistant A. baumannii and P. aeruginosa can be fatal and are particularly threatening for patients with weakened immune systems. There is an urgent need for new therapies to treat infections caused by microbes such as these that have developed resistance to current antibiotics, rendering these drugs ineffective.

Supporting Antibacterial Innovation

According to the WHO, an estimated 700,000 people die each year worldwide from bacterial infections. In the US, an estimated 23,000 people die each year from drug-resistant bacterial infections. In Europe, the number of deaths yearly is estimated at 33,000.

CARB-X partners have committed up to $500 million to invest in antibacterial R&D between 2016-2021. CARB-X’s goal is to support projects through the early phases of development through Phase 1, so that they will attract additional private or public support for further clinical development and approval for use in patients. These funds are in addition to investments made by the companies themselves. CARB-X provides between 80 and 90 percent of project costs, depending on the phase of development.

CARB-X is led by Boston University. Funding for the Techulon project is provided by the Biomedical Advanced Research and Development Authority (BARDA), the Wellcome Trust, Germany’s Federal Ministry of Education and Research (BMBF), and with in-kind support from National Institute of Allergy and Infectious Diseases (NIAID).

Tags: AntimicrobialsAwards
Previous Post

Florida’s Hepatitis A Outbreak Nears 3,000 Cases, Prompting Door-to-Door Vaccination Campaign

Next Post

Understanding Spatial and Temporal Patterns of Zika Transmission

Related Posts

Klebsiella pneumoniae
Antimicrobial Resistance

Inflammatix Wins BARDA Backing for Diagnostic to Rapidly Distinguish Bacterial from Viral Infections

25 Nov 2019
More People in the U.S. Dying from Antibiotic-Resistant Infections than Previously Estimated
Antimicrobial Resistance

More People in the U.S. Dying from Antibiotic-Resistant Infections than Previously Estimated

13 Nov 2019
Diagnosing Sepsis in Minutes: Cytovale Raises $15 Million in Financing
Biodetection

Diagnosing Sepsis in Minutes: Cytovale Raises $15 Million in Financing

9 Nov 2019
Debiopharm Progresses in Their Stand Against Drug-Resistant N. gonorrhoeae
Antimicrobial Resistance

Debiopharm Progresses in Their Stand Against Drug-Resistant N. gonorrhoeae

8 Nov 2019
Genomic Research Viruses
Industry News

Atriva Therapeutics Reports Results of Phase I Clinical Trial for ATR-002 Antiviral

8 Nov 2019
Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus
Biodetection

Aalto Bio Reagents Launches Protein for Detection of Venezuela Equine Encephalitis Virus

27 Oct 2019
Load More
Next Post
Asian Tiger Mosquito

Understanding Spatial and Temporal Patterns of Zika Transmission

Headlines

  • Artificial Intelligence and Big Data Analytics for Biodefence: Implications for Threat Assessment And Biosurveillance
  • African Swine Fever Kills More Than 20 Wild Boar in Poland
  • Samoa Measles Outbreak: Death Toll Rises To 53, Mostly Children
  • OPCW Defends Syria Attack Conclusions After Document Leaks
  • Osama bin Laden’s “Anthrax Scientist” Freed by Malaysia

Recommended

  • Highly Sensitive Epigenomic Technology Combats Disease
  • Interview: Ambassador Bonnie Jenkins on 8 years of Combating WMD Terrorism
  • There’s No Such Thing as Just-in-Time Healthcare and Public Health Preparedness
  • Threat Detection in Your Pocket
  • Inflammatix Wins BARDA Backing for Diagnostic to Rapidly Distinguish Bacterial from Viral Infections

Featured Partner

  • About
  • Contact
  • Privacy
  • Subscribe

© 2019 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • Pathogens
  • Directory
  • Job Board
  • Funding
    • Contracts + Grants
    • Funding Awards
    • Requests for Information
    • Industry News
  • Events
    • All Events
    • Conferences + Meetings
    • Deadlines
    • Webinar-Webcast
    • Awareness Events
  • Headlines
  • Subscribe

© 2019 Stemar Media Group LLC