Monday, May 23, 2022
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Biosecurity

Stopping Zika: Engineering an Alternative to ‘Suicide Mosquitoes’

by Global Biodefense Staff
February 14, 2021
A mosquito hangs from a leaf

Credit: Syed Ali / Unsplash

A new study from the University of Missouri and Colorado State University outlines the application of CRISPR gene-editing technology to produce mosquitoes that are unable to replicate Zika virus, rendering them unable to infect humans.

The Zika virus epidemic is a pressing public health emergency. In Brazil for example, there has been a 10-fold increase in newborns with microcephaly since October 2015, compared with previous years. Researchers have wrestled with various strategies for controlling the spread of Zika virus, which is transmitted to humans from female mosquito bites.

One approach, which was approved by the Environmental Protection Agency in May, will release more than 750 million genetically modified mosquitos into the Florida Keys in 2021 and 2022. These “suicide mosquitos” are genetically-altered to produce offspring that die before emerging into adults and therefore cannot bite humans and spread disease.

However, wiping out future generations of mosquitoes may cause environmental complications, such as potentially disrupting food chains. A new research study at the University of Missouri offers another option: genetically modifying mosquitoes to be resistant to Zika virus altogether.

Alexander Franz, an associate professor in the MU College of Veterinary Medicine, collaborated with researchers at Colorado State University by using CRISPR gene-editing technology to produce mosquitoes that are unable to replicate Zika virus and therefore cannot infect a human through biting.

“We genetically manipulated these mosquitoes by inserting an artificial gene into their genome that triggers one of the immune pathways in the midgut to recognize and destroy the RNA genome of Zika virus. By developing these mosquitoes that are resistant to the virus, the disease cycle is interrupted so transmission to humans can no longer take place.”

Alexander Franz, MU College of Veterinary Medicine

Franz added that the genetic modification is inheritable, so future generations of the altered mosquitoes would be resistant to Zika virus as well.

“We are interested in strategies for controlling insect vectors like mosquitoes that transmit various viruses affecting human health,” Franz said. “Public health experts suggest having a toolbox with different approaches available to tackle a virus such as Zika, and unfortunately right now there are limited options. There is no vaccine for the Zika virus widely available and spraying insecticides has become ineffective since the mosquitoes can develop resistance, so we are simply trying to expand the toolbox and provide a solution by genetically modifying the mosquitoes to become Zika-resistant while keeping them alive at the same time.”

Franz’ research is designed to help prevent another outbreak of Zika virus disease from occurring.

“If you can ever find a way to block the transmission of a pathogen that negatively affects humans, that is good news,” Franz said. “We have shown this is a viable option for genetically modifying mosquitos in a lab setting. There would need to be thorough discussions about regulatory compliance to see if this can be a solution out in the field down the road, and who knows when another Zika outbreak might happen in the future, which is why this research is so important.”

The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti. Viruses, 30 October 2020.

Related Reading:

  • Control of malaria-transmitting mosquitoes using gene drives Royal Society Publishing
  • Next-generation gene drive for population modification of the malaria vector mosquito PNAS
  • Efficient population modification gene-drive rescue system in the malaria mosquito Nature Communications
  • Project On Self-Deleting Genes Takes Aim At Mosquito-Borne Diseases Texas A&M Today
Tags: CRISPREditor PickGene DriveMosquito ControlMosquito-BorneTransmission DynamicsZika

Related Posts

U.S. Fish and Wildlife Service Opens Grant Program to Shore Up Avian Flu Biosecurity
Biosecurity

U.S. Fish and Wildlife Service Opens Grant Program to Shore Up Avian Flu Biosecurity

April 13, 2022
Send in the Blow Flies: Using Insects to Sample Areas for Chemical Warfare Agents
CBRNE

Send in the Blow Flies: Using Insects to Sample Areas for Chemical Warfare Agents

April 11, 2022
Johns Hopkins: Chemical in Leafy Greens May Slow Growth of Coronaviruses
Pathogens

Johns Hopkins: Chemical in Leafy Greens May Slow Growth of Coronaviruses

April 11, 2022
Bird Flu is Killing Millions of Chickens and Turkeys Across the US
Biosecurity

Bird Flu is Killing Millions of Chickens and Turkeys Across the US

April 7, 2022
Load More

Latest News

NIH to Further Invest in Point-of-Care Technologies Research Network

NIH to Further Invest in Point-of-Care Technologies Research Network

May 10, 2022

How a COVID-19 Infection Spurs Antibodies Against Common Colds

May 8, 2022
Hospitals Resilience to Extreme Events: One-Third of Staff May Be Lost During a Disaster

Hospitals Resilience to Extreme Events: One-Third of Staff May Be Lost During a Disaster

May 6, 2022
Where is Testing Needed Most During Pandemic Surges? WVU Researchers Develop Machine Learning Prediction Tools

Where is Testing Needed Most During Pandemic Surges? WVU Researchers Develop Machine Learning Prediction Tools

May 6, 2022

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC