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Home CBRNE

Radiation Countermeasures: Q-3-R Alleviates Radiation-Induced Lung Inflammation and Fibrosis

by Global Biodefense Staff
February 27, 2022
Radiation Countermeasures: Q-3-R Alleviates Radiation-Induced Lung Inflammation and Fibrosis

Two U.S. Airmen from the 193rd Special Operations Wing, Pennsylvania Air National Guard, use ADM-300 survey meters to test for a radiation source, during a radiation exercise. They were part of the initial-entry team whose job was to identify radiation check-sources in the contaminated zone. Credit: Tony Harp

Radiation exposure to lungs during nuclear catastrophes or radiotherapy poses long-term side effects and can induce pulmonary injury sufficient for causing death. The strategies for preventing or reversing radiation-induced lung injuries have not been yet developed. Quercetin-3-Rutinoside (Q-3-R), a polyphenolic bioflavonoid, has shown multifaceted pharmacological applications due to its high antioxidant and anti-inflammatory properties.

In this mouse study, researchers assessed the potential of Q-3-R against radiation-induced lung pneumonitis/fibrosis and the possible underlying mechanism.

The findings demonstrate that Q-3-R provides radioprotection to the lungs by regulating NF-κB/TGF-β1 signaling, scavenging free radicals, preventing perivascular infiltration and prolonged inflammatory cascade which could otherwise lead to chronic radiation fibrosis.

Q-3-R can be proved as a potential therapeutic agent for alleviating radiation-induced lung injury in case of planned or unplanned radiation exposure scenario.

Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling. Phytomedicine. May 2022

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Tags: Editor PickMass CasualtyRadiation

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