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    Pathogens

    A Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin

    By Global Biodefense StaffFebruary 3, 2020
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    NOTE: The following paper (.pdf) is undergoing accelerated peer-review. Abstract follows:

    Since the SARS outbreak 18 years ago, a large number of severe acute respiratory syndrome-related coronaviruses (SARSr-CoV) have been discovered in their natural reservoir host, bats 1–4 . Previous studies indicated that some of those bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a novel coronavirus (2019-nCoV) which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started from 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the early stage of the outbreak. They are almost identical to each other and share 79.5% sequence identify to SARS-CoV. Furthermore, it was found that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. The pairwise protein sequence analysis of seven conserved non-structural proteins show that this virus belongs to the species of SARSr-CoV. The 2019-nCoV virus was then isolated from the bronchoalveolar lavage fluid of a critically ill patient, which can be neutralized by sera from several patients. Importantly, we have confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.

    These authors contributed equally: Peng Zhou, Xing-Lou Yang, Xian-Guang Wang

    A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature https://doi.org/10.1038/s41586-020-2012-7 Published 03 February 2020

    This article is published on Global Biodefense under a CC4.0 License.

    DISCLAIMER

    This information is not intended as medical advice or clinician guidance. This content contains edited excerpts to bring attention to the work of the researchers and study authors. Please support their efforts and click through for the full context.

    Coronavirus COVID-19 Magazine Edition 6 Feb 2020
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