The Center for Inherited Disease Research (CIDR) at Johns Hopkins University has been awarded continuation funding from the National Institutes of Health (NIH) for DNA research to support development of preventive and therapeutic interventions to combat disease.
The award funds CIDR to provide expertise in statistical genetics and genomic analysis using methods designed to find the genetic basis for disease. These services support extramural and intramural research programs funded by fourteen participating institutes including the National Human Genome Research Institute (NHGRI) and National Cancer Institute (NCI). The contract includes requirements such as:
-SNP genotyping of human immune response genes using approximately 200,000 SNPs on 8,000 samples per year.
-Single nucleotide genotyping (SNP) to allow whole genome linkage scans of at least 10,000 human samples per year.
-SNP genotyping using custom designed assay for 96 to 500,000 user selected SNPs on approximately 36,000 samples per year.
-Fixed content genotyping on platforms capable of scoring 500,000 to 5,000,000 uniformly spaced loci to allow SNP whole genome association scans of approximately 100,000 human samples per year. These assays will be designed to capture >90% of the variation in human DNA when taking human linkage disequilibrium into account, for the purposes of genome-wide association studies.
-SNP genotyping using approximately 200,000 SNPs covering the genes in human metabolism in approximately 35,000 samples per year.
-SNP genotyping of up to ~1500 SNPs in approximately 5,000 mouse DNA samples per year.
-Measure DNA methylation in human samples using arrays that cover 10,000 to 250,000 potential sites of methylation in the human genome in approximately 15,000 samples per year.
-Carry out whole exome sequencing of human DNA for approximately 1,000 exomes per year.
Other requirements of the contract include provision of expert consultation on statistical genetics questions, analysis of genotyping data after production genotyping is complete, and maintenance of appropriate data analysis systems and records.
The Center for Inherited Disease Research (CIDR) was established at the Johns Hopkins University in 1996. To date, CIDR has completed studies encompassing over 140 phenotypes across 450 projects and 500,000 samples.
The contract award dollar amount is not to exceed $101,892,223 over 5 years. The period of performance is June 1, 2012 through May 31, 2017.