Wednesday, August 10, 2022
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Pathogens

Why Men and Women Respond Differently to Vaccines

by Global Biodefense Staff
December 30, 2013

A new study has identified a link between certain genes affected by testosterone and antibody responses to an influenza vaccine. The findings, published in Proceedings of the National Academy of Sciences, suggest that testosterone levels may partially explain why men often have weaker responses to vaccines than women.

Previous research has shown that men typically experience more severe viral and other microbial infections than women, who tend to mount stronger immune responses to infections and vaccinations. In the new study, researchers analyzed the antibody responses of 53 women and 34 men of various ages to the 2008-2009 seasonal influenza vaccine. Compared to the men, the women produced antibodies that in laboratory tests could more effectively neutralize the influenza virus.

To explain this difference, the scientists searched for patterns in gene expression, or the degree to which specific genes are turned on or off. They found that men with weak vaccine responses tended to have high expression levels of a certain cluster of genes involved in the metabolism of lipids (fats). Previous studies have suggested that testosterone may regulate the expression of many of these genes.

The researchers found that men with high levels of testosterone and elevated expression of the gene cluster had weaker antibody responses to the vaccine than women and men with low testosterone. These results suggest that testosterone may suppress immune responses to vaccines by altering expression patterns of specific genes, but further research is needed to determine the mechanism.

The study, led by researchers at Stanford University, was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health.

Read the study at PNAS: A systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. 

Tags: Vaccines

Related Posts

Bacteria That Causes Melioidosis Confirmed in Environmental Samples in Mississippi Gulf Coast
Pathogens

Bacteria That Causes Melioidosis Confirmed in Environmental Samples in Mississippi Gulf Coast

July 27, 2022
Monkeypox Transmission: Virus Detected in Saliva, Bodily Fluids
Infectious Diseases

Monkeypox Transmission: Virus Detected in Saliva, Bodily Fluids

July 17, 2022
Pathogen Crescendo: Brass, Woodwinds Section Emit Respiratory Particles
Pathogens

Pathogen Crescendo: Brass, Woodwinds Section Emit Respiratory Particles

July 16, 2022
Poxvirus Proteins Enable Early Strike on Immune Defences
Pathogens

Poxvirus Proteins Enable Early Strike on Immune Defences

July 15, 2022
Load More

Latest News

Bacteria That Causes Melioidosis Confirmed in Environmental Samples in Mississippi Gulf Coast

Bacteria That Causes Melioidosis Confirmed in Environmental Samples in Mississippi Gulf Coast

July 27, 2022
Monkeypox Transmission: Virus Detected in Saliva, Bodily Fluids

Monkeypox Transmission: Virus Detected in Saliva, Bodily Fluids

July 17, 2022
Influenza Transmission Spikes During Social Gatherings

New Universal Flu Vaccine Offers Broad Protection Against Influenza A Virus Infections

July 17, 2022
Long COVID: National Academies’ Panel Examines Long-Term Health Effects of COVID-19

Long COVID: National Academies’ Panel Examines Long-Term Health Effects of COVID-19

July 17, 2022

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC