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Home Funding News

NHP Models for Understanding Host-Pathogen Interactions

by Global Biodefense Staff
November 17, 2015
Quantitative Viral Outgrowth Assay

Credit: Shutterstock

The National Institutes of Allergy and Infectious Diseases (NIAID) has announced intentions to expand an existing contract with Emory University for an effort entitled “An Integrated Approach to Understanding Host-Pathogen Interactions.”

This project aims to demonstrate the utility and value of systems vaccinology for malaria vaccine development with the benefits of established non-human primate (NHP) model systems.

The work consists of experiments that involve immunizing rhesus monkeys with irradiation-attenuated Plasmodium cynomolgi sporozoites (multiple strains) to identify molecular signatures associated with immunity and protection. Omics data analysis and integration will be performed as well as in-depth immune profiling to assess changes in frequencies and activation status of approximately 30 cellular subsets comprised of neutrophils, monocytes, B-cells, dendritic cells, and T-cells.

The original contract was awarded on a competitive basis for a five-year period (inclusive of options) which ends in Sept. 2017, with a total potential value of $19,458,981.  The objective of the current acquisition is to increase the quantity of labor hours delivered through the remainder of the current contract.

The expansion will build upon a large body of systems biology data generated on the natural course of infection, immunity and pathogenesis in NHP models for the widespread human malaria pathogen, P. vivax.

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Tags: Animal ModelsMalariaVaccines

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