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BD21 Biosensor Redesign: DHS Seeks Contractors to Improve Urban BioThreat Classification Sensor

by Global Biodefense Staff
September 3, 2021
BD21 Biosensor Redesign: DHS Seeks Contractors to Improve Urban BioThreat Classification Sensor

DHS CWMD is leading an effort to develop the next-generation of aerosol biodetection systems

RFIs open for Advanced Sensor Redesign and UV-LIF Trigger Redesign

The Department of Homeland Security CWMD Research & Development division is seeking information from contractors capable of supporting its requirements for the development of more affordable aerosol biosensors that operate and alert in real time and are capable of detecting and characterizing or identifying biological agents in operational environments.

The Biodefense for the 21st Century (BD21) program is working to design, develop, and deploy networked detection systems that continuously monitor the air, collect real-time data, and employ data analytics to detect anomalies. The faster anomalies are detected, the faster first responders can address potential threats.

The BD21 Program Management Office has identified the need for further research and development of commercially available biological detection and presumptive identification technologies to enable timely detection and characterization of airborne bio-threats.

The DHS CWMD office intends to deploy biosensors in both indoor and outdoor urban environments to conduct real-time monitoring of biological threats and seeks industry to continue research and development efforts in order to meet characterization and cost goals. The redesign of the commercially available biosensors is being proposed to occur over 15 months and will take place in 2 phases, to include: the design of at least 2 prototypes that will be tested by the performer followed by an opportunity for a prototype redesign before delivering the final prototypes to the government for an independent operational background test and chamber test.

Minimum requirements for the sensors include:

  • Capable of accurately detecting and classifying Category A and B biological agents in environmental aerosols with varying levels of background particles.
  • Capable of continuous monitoring of aerosols.
  • Capable of sending alerts to an operator after detection, characterization and/or preliminary identification within a maximum time of 30 minutes.
  • Ability to differentiate between biological and non-biological particles while rejecting benign particles that are common interferents such as brake dust and diesel smoke.
  • Sensors must be capable of classification of biological particles to a Kingdom level at minimum (bacteria, virus, toxin, spore).
  • Sensor differentiation of particles should reduce false alarms in urban operational environments to a level of < 3 alarms/day.
  • Sensors must be capable of detecting down to a 1um particle size at concentrations relevant to a 3kg (threshold), 0.5kg (objective) times aerosolized release based on biological particle type.

Select background slides from the 18 March 2021 BD21 Virtual Industry Day:

Biosensor Anomaly Detection Algorithm – BD21. Credit: DHS CWMD
Continuous monitoring provides real-time analysis of the environment. Sensor data feeds into anomaly detector. Used in conjunction with air collection and field screening technology. Example modalities: Light-induced Florescence, RAMAN, Mass Spec
Credit: DHS CWMD
Improved affordability, better species level of classification (such as for Bacillus anthracis), differentiate vegetative and sporulated bacteria, and classification of benign particles such as cleaning materials, brake dust and smoke
Credit: DHS CWMD
Timely classification of biological concerns, which include bacterial spores, vegetative bacteria, viruses and toxins. Also need to improve detection response time using real-time bio-aerosol sensors
Credit: DHS CWMD
Current trigger sensors collect data using ultra-violet laser-induced fluorescence (UV-LIF) to determine if particles are biological. UV-LIF is susceptible to interferents that fluoresce in the same emission and excitation regions. Difficult to differentiate pathogens of interest from background pathogens. Combining UV-LIF sensors with complimentary excitation/emission wavelengths can further reduce false alarms by requiring multiple emission wavelengths for detection
Credit: DHS CWMD
Sensor redesign may require development redesign of classification algorithm to differentiate between vegetative and sporulated bacteria. UV-LIF sensors report pollen spores as fluorescent particle and are unable to distinguish from sporulated bacteria. High-confidence sensors would look at the genetic sequence and for sequencing techniques identify spores
Credit: DHS CWMD
Biological particles examples: pollen, native non-pathogenic bacteria, fungal spores, human-like substances. Non-biological aerosol examples: diesal soot, polycyclic aromatic hydrocarbons, dust
Credit: DHS CWMD
Bacterial species size range: 1-10 micrometers (μm), viruses range approximately 10-100 nanometers, and toxins range from approximately 1-10 nanometers. The small scale of viruses make detection challenging unless there is a high concentration of virions or they clump to form larger particles.
Credit: DHS CWMD
UV-LIF Trigger Redesign and Advanced Sensor Redesign Efforts Kick off Q1 FY2022 (Federal)
Credit: DHS CWMD

Contractors shall deliver two instruments of the same version for each of the of development prototype phases. The government anticipates the sensors per unit cost will be between $125K (threshold) and $65K (objective).

Additional details are available at SAM.gov Notice ID: 70RWMD21RFI00000011 and 70RWMD21RFI00000012. The current response deadline is Sep 16, 2021.

Tags: BD21BioterrorismBioWatchDHSEditor PickOpportunitiesRFI

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