Are systemic reactions more common after simultaneous administration of COVID-19 mRNA booster and seasonal influenza vaccines than after COVID-19 mRNA booster alone?
Findings from this study suggest that simultaneous administration of COVID-19 mRNA booster and influenza vaccines may be associated with a slightly increased likelihood of systemic reactions.
Self-reported data from 981,099 persons aged 12 years or older given simultaneous administration of a COVID-19 mRNA booster dose and an influenza vaccine was associated with 8% to 11% increases, respectively, in systemic reaction compared with COVID-19 mRNA booster alone.
In both groups, most reactions reported in the week following vaccination were generally mild.
Reactogenicity of Simultaneous COVID-19 mRNA Booster and Influenza Vaccination in the US. JAMA Network Open, 15 July 2022.
Read also:
Perspective: More (mostly mild) side effects when flu vaccine given with COVID booster. CIDRAP
Vaccine efficacy and immune interference: co-administering COVID-19 and influenza vaccines. The Lancet Respiratory Medicine
Acceptance of COVID-19 and Influenza Vaccine Co-Administration: Insights from a Representative Italian Survey. Journal of Personalized Medicine
Immunogenicity of third dose of anti-SARS-CoV-2 vaccine co-administered with influenza vaccine: An open question. Human Vaccines & Immunotherapeutics
COVID-19 and Seasonal Influenza Vaccination: Cross-Protection, Co-Administration, Combination Vaccines, and Hesitancy. Pharmaceuticals
Comments on vaccine coadministration – 21st Meeting of the European Technical Advisory Group of Experts on Immunization (ETAGE) – Nov 2021. World Health Organization
Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine
