Revive Therapeutics Ltd. today announced that it has filed a provisional patent application titled “Compositions, methods and uses of Bucillamine in the treatment of a victim exposed to a chemical warfare agent.”
The methods and compositions described in the patent application relate to Bucillamine as a potential treatment of a victim exposed to a chemical agent, including chemical warfare agents such as sulfur mustards, nitrogen mustards, nerve agents of G and V type, lewisite and adamsite.
On July 6, the Revive announced the results of its Phase 3 clinical study evaluating the safety and efficacy of oral Bucillamine in patients with mild to moderate COVID-19. The study did not achieve statistical significance on the clinical endpoints.
According to the U.S. Department of Homeland Security, a chemical attack is the spreading of toxic chemicals with the intent to do harm, which may include chemical weapons (warfare agents) developed for military use, toxic industrial and commercial chemicals that are produced, transported, and stored in the making of petroleum, textiles, plastics, fertilizers, paper, foods, pesticides, household cleaners, and other products, and chemical toxins of biological origin such as ricin.
Revive Therapeutics is commencing work with advisors in developing a strategic plan to present its case in repurposing Bucillamine as a potential medical countermeasure for chemical warfare agent exposures to the Biomedical Advanced Research and Development Authority (BARDA), a part of the Administration for Strategic Preparedness and Response (ASPR) in the U.S. Department of Health and Human Services.
Bucillamine is currently indicated to treat rheumatoid arthritis in Japan and South Korea.