Close Menu
    Facebook X (Twitter) Instagram
    Facebook Instagram Threads
    Global BiodefenseGlobal Biodefense
    Subscribe
    • Featured News
    • Funding
    • Directory
    • Jobs
    • Events
    Global BiodefenseGlobal Biodefense
    Biosecurity

    New Antibody Weapons Against Marburg Virus

    By Global Biodefense StaffJune 29, 2015
    Marburg Antibodies Diagram
    Antibodies that identify and neutralize Marburg virus. Credit: TSRI
    Share
    Facebook LinkedIn Reddit Email
    Marburg Antibodies Diagram
    Antibodies that identify and neutralize Marburg virus. Credit: TSRI

    A new study led by scientists at The Scripps Research Institute (TSRI) identifies new immune molecules that protect against deadly Marburg virus, a relative of Ebola virus. The research provides ingredients needed to develop treatments for future Marburg outbreaks.

    “These antibodies attack a new site on Marburg virus we had not seen before,” said Erica Ollmann Saphire, senior author of the new study, professor at TSRI and director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium.

    The new antibodies that identify and neutralize Marburg virus–which has a mortality rate of up to 90%–were developed through an academic-industrial partnership including TSRI, Integrated Biotherapeutics, Mapp Biopharmaceutical and Emergent BioSolutions. Currently, there are no vaccines or treatments specifically for Marburg infections.

    The findings were published in the journal PloS Pathogens.

    New Tools to Fight Marburg Virus

    The new study builds on previous work in Saphire’s lab revealing a molecular structure that Marburg virus uses to attach to and enter host cells.

    To defeat Marburg virus, scientists are looking for vulnerable sites on the virus’s surface where an antibody can bind. Previous research, including trials with the experimental ZMapp treatment, shows that mixtures or “cocktails” of antibodies can block Ebola virus from infecting new cells and alert the immune system to the presence of the infection.

    It’s thought that a similar cocktail strategy could work against Marburg virus. Antibodies against one site on Marburg were revealed in a study by Vanderbilt University and TSRI in February 2015, but complementary antibodies needed against other sites remained to be discovered.

    In the new study, TSRI researchers designed proteins which elicited new antibodies developed at Emergent BioSolutions. Other antibodies in the study were independently identified at Mapp Biopharmaceutical and Integrated Biotherapeutics, which collaborated with TSRI for molecular analysis.

    Some of the new antibodies target a new site on Marburg virus not seen before–a wing-like feature attached to the base of the virus. Antibodies against this newly discovered site protected 90 to 100% of infected animal models from lethal infection.

    Ebola Virus Also Vulnerable

    Some antibodies discovered in the new study are also able to cross-react with Ebola virus and its four relatives in the Ebolavirus genus.

    “We expect both Marburg virus and Ebola virus to emerge again and to acquire new mutations,” said TSRI Research Assistant Marnie Fusco, first author of the new study. “The cross-reactive antibodies could be used as diagnostics for newly emerging strains.”

    “The high cost of creating independent vaccines or treatments for each of the different viruses in this family necessitates intelligent design of immunogens (antibody-inducing molecules). The molecular images used to design the molecules and evaluate the antibodies point the way forward,” added Jody Berry, the former Director of Pipeline Research of Emergent BioSolutions, who initiated the study with Saphire six years ago.

    “Understanding where and how the antibodies interact with the virus tells us which regions can be targeted and helps us develop lead candidates for clinical development,” said Cory Nykiforuk, current director of pipeline research of Emergent BioSolutions. “There are multiple filoviruses that threaten our communities, front line medical workers and defense personnel, and bringing new technologies to the forefront could potentially help meet future requirements.”

    Read the study: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs.

    Animal Models Ebola Marburg
    Share. Facebook LinkedIn Reddit Email
    Previous ArticleBiodefense Headlines – June 28, 2015
    Next Article CDC Panel Releases Ruling on Meningococcal B Vaccines

    Related Stories

    Chlorine Exposure Biomarkers in a Large Animal Model

    December 5, 2023

    Human BCG Challenge Model for Assessment of Tuberculosis Immunity

    December 2, 2023

    Needle-Free Vaccine Patch Against Zika Virus

    December 2, 2023

    Black Death Impact on Microbiome May Have Contributed to Modern-Day Chronic Diseases

    November 29, 2023
    News Scan

    Biodefense Headlines – 30 November 2023

    News Scan November 30, 2023

    News highlights on health security threats and countermeasures curated by Global Biodefense This week’s selections include the largest ever outbreak of mpox in the DRC; launch of National Wastewater Surveillance Program dashboard; low uptake of COVID-19 boosters and flu vaccines;…

    Upcoming Events

    Mar 12
    Hybrid Hybrid Event
    March 12, 2024 - March 17, 2024

    2024 Fungal Genetics Conference

    Mar 21
    March 21, 2024 - March 23, 2024

    ASPPH 2024 Annual Meeting

    View Calendar

    Subscribe to Global Biodefense

    Get the latest news on pathogens and preparedness

    News on pathogens and preparedness for public health emergencies

    © 2023 Stemar Media Group LLC
    • About
    • Contact
    • Privacy
    • Subscribe

    Type above and press Enter to search. Press Esc to cancel.