Sensitive and convenient detection methods for amino alcohol are of great importance to identify nitrogen mustard exposure in forensic analysis.
As blister agents, these nitrogen mustards could cause injuries to mucous membranes by alkylating free affinity sites present in biomolecules, which can even lead to physiological abnormalities or death. The chemical synthesis of sulfur mustards or nitrogen mustards could be achieved with commercially available reagents and convenient experimental procedures, in contrast to the complex processes involved in synthesizing nerve agents.
In a new study, a GC-MS/MS method for simultaneous quantification of nitrogen mustard metabolites both in plasma and urine was established and fully validated.
Fluoride derivatization-enabled sensitive and simultaneous detection of biomarkers for nitrogen mustard in human plasma and urine via gas chromatography tandem mass spectrometry. RCS Advances, 14 September 2023.