General Considerations of Using NHP in Preclinical Ocular Drug Research

This webinar will discuss the basic biology of the NHP eye compared to human and other species (rabbit and rodents) in anatomy and physiology, as well as the advantages and concerns of using the NHP eye in preclinical ocular research and drug discovery.

Experts will share major background findings in ocular toxicity studies in different types of test articles (biologics and gene therapy) in different species.

The origin and principle of immunogenicity in preclinical ocular studies will be discussed, along with representative images of ocular immunogenicity findings, and experience in risk mitigation strategies.

The speaker will introduce NHP ocular disease models, and present examples of using these models for efficacy studies with different routes of administration. Ophthalmic endpoints for ocular efficacy and toxicity studies will be discussed, with typical ocular findings related to the immune and test articles.

Please visit SOT’s Ocular Toxicology event page to register for this webinar.