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    Antimicrobial Resistance

    DTRA Seeks Chem-Bio Research Concepts for SEED Funding

    By Global Biodefense StaffJuly 25, 2012
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    The Defense Threat Reduction Agency this week announced a new Broad Agency Announcement (BAA) amendment to solicit research proposals for the Chemical and Biological Defense Program.

    The effort supports Strategic Exploratory Developments (SEEDs), which enable science and technology managers within the Chem-Bio Technologies Directorate to explore concepts for new programs in science and technology.

    SEED investments are generally $50K to $500K for a one year contract that explores new concepts to fill capability gaps.  If the SEED contract yields a successful proof of concept, the Government may procure further development of the science and technology of the SEED through a Focused Innovation Technology (FIT) contract.  FITs are typically longer in duration than SEEDs with increased funding levels.

    SEED Topics of interest include:

    Identification of Staphylococcal Enterotoxin B (SEB) Vaccine Candidates
    Novel Small Molecule Nerve Agent Pretreatments
    Target Identification for Next Generation of Medical Countermeasures
    Rapid Interior Decontamination
    Facilitating Blood Brain Barrier Penetration of Nerve Agent Countermeasures
    Catalytic Antibodies Against a VX Surrogate
    Impact of Adjuvants on Current Vaccine Candidates
    Novel Vaccines Directed Against Burkholderia pseudomallei and Burkholderia mallei
    Alphavirus and Filovirus Target-Directed Small-Molecule Therapeutic Discovery and Development
    Thermostable Protein Engineering or Stabilization
    Epitope Mapping for Antibodies that Recognize Biothreat Agents
    Nano-Enabled Low-Cost Sensors
    Biomolecule Theoretical and Experimental Sub-THz and THz Range Signature Development
    Super-Continuum Laser Source IR 1-15 microns
    Native Chemical Sensing Capabilities
    Novel Sample Stabilization Technologies
    Single Cell Analysis: In situ Biomarker Expression Methods
    Antibiotic Resistance Markers
    Diagnostic Device Use Case Development in Austere Environments
    Autonomous Mobile Sensing Demonstration
    Mitigation of Porous and Absorptive Materials
    Biomanufacturing Downstream Process Technologies
    Universal Nano-Adjuvant System
    Smart Molecular Tags for Improving Biotherapeutic Production and Enhancing Biological Activity

    Further details on each topic area are available under HDTRA1-12-CHEM-BIO-BAA Amend 22. The submission deadline is no later than October 5, 2012. Proposals are typically evaluated within 45 days of receipt.

    BAA Biomarkers Bioscavengers Burkholderia Defense Threat Reduction Agency Nanotech Ruggedized Thermostability
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