Saturday, March 18, 2023
News on Pathogens and Preparedness
Global Biodefense
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe
No Result
View All Result
Global Biodefense
No Result
View All Result
Home Antimicrobial Resistance

SEB Biodefense Vaccine Starts First Human Clinical Trial

by Global Biodefense Staff
February 26, 2013

Staphylococcal Enterotoxin B moleculeIntegrated BioTherapeutics Inc. (IBT), a biotechnology company developing medical countermeasures for biodefense and emerging infectious diseases, this week announced the initiation of a Phase 1 clinical trial testing the safety and immunogenicity of its staphylococcal enterotoxin B vaccine “STEBVAX”.

STEBVax is a proprietary, attenuated form of Staphylococcal Enterotoxin B (SEB), a member of a group of toxins called superantigens due to the ability to cause a massive inflammatory response leading to toxic shock. The trial marks the first time a superantigen vaccine has been administered to humans.

“SEB is a biowarfare threat to the US and the superantigens can be critical factors affecting the outcome of Staphylococcus aureus infections,” said Dr. M. Javad Aman, IBT President and Chief Scientific Officer. “This clinical study advances our vaccine programs designed to protect military and civilian populations against the threat of SEB and our long-term goal of developing vaccines and therapeutics for Staphylococcus aureus.”

When purified, SEB is a potential bioweapon and was pursued by the US and USSR prior to an international ban on offensive biological and chemical weapons. STEBVax is considered a stand-alone vaccine for biodefense applications but is also a component of IBT’s multivalent vaccine for prevention and treatment of staphylococcal infections in civilian life, a pressing public health problem in light of growing antibiotic resistance. The prospective multivalent vaccine will contain additional toxoids including other attenuated superantigens and pore-forming toxins currently in pre-clinical development at IBT.

The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and will be conducted at the Center for Vaccine Development at the University of Maryland in Baltimore, which is one of NIAID’s Vaccine and Treatment Evaluation Units (VTEUs). 

“We are extremely pleased to see a decade-long research and development effort, which was heavily supported by the government, reach this critical milestone,” said Aman.

IBT has a history of working with the government to develop biodefense countermeasures. In 2012, the company received a two-year NIAID grant to further develop a proprietary second generation vaccine against viral hemorrhagic fever caused by the deadly Ebola and Marburg viruses. The vaccine would potentially provide protection against all major species of filoviruses. 

Sources: PRNewswire, IBT. Image credit: Birkbeck University of London.

Tags: EbolaVaccines

Related Posts

DARPA Selects Teams to Develop Vaccine Durability Prediction Model
Medical Countermeasures

DARPA Selects Teams to Develop Vaccine Durability Prediction Model

January 13, 2023
small glass vials on an assembly line await filling of vaccine solution
Industry News

Sabin Vaccine Institute to Advance Ebola Sudan and Marburg Vaccines with New BARDA Funding

January 12, 2023
How Are Bivalent COVID Vaccines Stacking Up Against Omicron?
Infectious Diseases

How Are Bivalent COVID Vaccines Stacking Up Against Omicron?

January 12, 2023
NISTCHO: New Living Reference Material for Producing Monoclonal Antibodies
Medical Countermeasures

NISTCHO: New Living Reference Material for Producing Monoclonal Antibodies

January 12, 2023
Load More

Latest News

Biodefense Headlines – 12 March 2023

Biodefense Headlines – 12 March 2023

March 12, 2023
Partner Therapeutics’ Novel Approach to Stratify Sepsis Patients Gains Backing From BARDA

Biopreparedness Research Virtual Environment (BRaVE) Initiative Backed by $105M DOE Funding

January 25, 2023
Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

Influenza Proteins Tilt and Wave in ‘Breath-like’ Motions

January 25, 2023
Biodefense Headlines – 24 January 2023

Biodefense Headlines – 24 January 2023

January 24, 2023

Subscribe

  • About
  • Contact
  • Privacy
  • Subscribe

© 2022 Stemar Media Group LLC

No Result
View All Result
  • Featured
  • COVID-19
  • Funding
  • Directory
  • Jobs
  • Events
  • Subscribe

© 2022 Stemar Media Group LLC

We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are okay with it.OkPrivacy policy