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Home Industry News

Profectus Biosciences Awarded Funding for Ebola Vaccine

by Global Biodefense Staff
October 15, 2014
Ebola Vaccine Research

The Department of Health and Human Services Office of the Assistant Secretary for Preparedness & Response (ASPR) this week awarded funding to Profectus BioSciences, Inc. to support advanced development of the company’s rVSV-vectored Ebola and Marburg virus vaccine.

The vaccine is based on the live attenuated rVSVINN4CT1 clinical vector, which has successfully completed phase 1 safety and immunogenicity testing as an HIV vaccine candidate (HVTN trial 090).

To provide protection against all filoviruses, the Profectus vaccine contains a blend of three rVSVN4CT1 vectors expressing the G proteins from S-EboV, Z-EboV, and MarV. In support of animal model development, Profectus provided the Z-EboV-rVSVN4CT1 and MarV-rVSVN4CT1 vaccines for two FANG-coordinated non-human primate challenge studies conducted under NIAID’s preclinical services program.

In an early study, a single IM dose of the Z-EboV-rVSVN4CT1 vaccine completely protected 3 cynomolgus macaques against challenge 28 days later with a lethal dose (1,000 pfu) of low passage Z-EboV, while 3 non-vaccinated macaques succumbed to lethal disease. Twenty eight days after the first challenge, the protected macaques were then challenged with a lethal dose (1,000 pfu) of low passage S-EboV. Two of three were protected, even though S-EboV is distantly related to Z-EboV.

In a second study, a single dose of the MarV-rVSVN4CT1 vaccine completely protected 2 cynomolgus macaques against lethal challenge 28 days later with low passage MarV, while 2 non-vaccinated macaques succumbed.

Additional biodefense programs at Profectus include vaccines against Lassa and Chikungunya viruses utilizing the vesiculovirus platform.

The contract is valued at $8,620,131 and was announced under Solicitation Number: CBRN-BAA-13-100-SOL-00013.

Tags: Animal ModelsASPREbolaHHSLassa FeverMarburgVaccines

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