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    Biodetection

    ADI Offers Ebola ELISA Test Kits for Humans and Animals

    By Global Biodefense StaffOctober 28, 2014
    Alpha Diagnostic International
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    Alpha Diagnostic Int’l (ADI) has announced availability of several rapid, and sensitive ELISA test kits for the detection of major Ebola viral protein antibodies including Glycoprotein (GP), Nucleoprotein (NP), and Viral Protein 40 (VP40).

    The antibody ELISA kits are available not only for human samples; but also for monkey, dog and mouse samples in support of Ebola countermeasures research in animal and primate models.

    ADI’s test kits can be used to determine if Ebola survivors have antibodies prior to giving a blood donation.  “More importantly, a population survey can be done to determine the immunity levels of Ebola in endemic regions,” said Dr. Masarrat Ali, Director of ADI.

    The levels of antibodies sufficient enough to provide immunity also need to be established.  ADI has made similar antibody kits for dog and pig samples to establish if the animals from Ebola endemic regions have any circulating Ebola virus protein antibodies and, therefore, exposed to Ebola virus.

    The antibody ELISA kits are highly sensitive and need only a tiny drop of blood or serum to conduct the test within two hours.

    The United States, United Kingdom, and Canada have started clinical trials on the most promising candidates for Ebola vaccines.  These vaccines use an adenovirus (chAd3) or vesicular stomatitis virus (VSV) vectors to deliver one of the most antigenic Ebola virus’s Glycoprotein (GP) in order to induce antibodies in humans or primates.  “ADI’s Ebola virus GP antibody ELISA tests along with the chAd3 and VSV protein antibody ELISA kits will allow for immediate assessment of vaccine efficacy,” said Dr. Ali.

    Zmapp, an experimental therapeutic cocktail of three humanized GP monoclonal antibodies, has been used in some Ebola patients in order to neutralize the Ebola virus.  The U.S. Department of Health and Human Services has provided $42.3 million to help San Diego-based Mapp Biopharmaceutical accelerate the development and testing of ZMapp.  ADI has developed ELISA kits to not only measure the Zmapp antibody concentration in its purified form but also after infusion to humans or animals.

    For example, it is possible to establish the levels of Zmapp in Dr. Brantly’s blood immediately after the first dose and then weeks and months afterwards.  It is also now possible to assess what levels of Zmapp, natural antibodies, or antibodies induced by vaccines are sufficient to prevent an Ebola infection. The Ebola antibodies test is conducted in less than two hours in a laboratory in field setting with minimal instruments or equipment.

    Additional rapid tests, similar to pregnancy tests, have been developed to quickly identify and assess the activity of Zmapp in 2-5 minutes.  “These tests will not only help in the manufacturing and quality control of Zmapp but also prevent any fraudulent marketing of the drug,” said Dr Ali.

    “The availability of these kits should help diagnose Ebola in humans and animals and allow for rapid testing of various Ebola vaccines,” said Dr. Ali.

    ADI, established in 1993 in San Antonio, Texas, USA, is a biotech company engaged in developing and testing vaccines for malaria, cholera, anthrax, Ebola, Japanese encephalitis, universal influenza, Congo, and papilloma (HPV) viruses.

    Source: ADI press release, adapted.

    Adenovirus Animal Models Ebola
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